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Molecular Mechanisms Associated With Acute Myeloid Leukemia: Review Article

Year: 2013

Type: article

Abstract: The present review article purposes to introduce the molecular mechanisms underlying acute myeloid leukemia (AML). An overview of AML was introduced including its classification, therapeutic options and the roles of mutations in p53 and WT1 genes. The possibility of molecular targeting therapies was also discussed. The efforts of many researchers concerning AML were taken into consideration during this review. We also pointed to the various roles of WT1 gene as suppressor or oncogene. The important relationship between p53 gene and WT1 gene was highlighted so that when WT1 gene stabilizes p53, the pathological picture concerning p53 if being mutated or not should be reconsidered again.

Source: European Scientific Journal ESJ

Authors: Mohammed Al Asseri, Ahed J Al Khatib, A'aesha M Qasem, Abdullah Hamadi, Fatima Laiche

Institutions: Jordan University of Science and Technology, University of Tabuk, Université de Mostaganem

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W1537058404

FWCI:

Cites: 44

Cited by:

Related to: 10