Year: 2004
Type: dissertation
Abstract: An estimated 4 to 5 million individuals in the Netherlands are actively infected with \nHelicobacter pylori. Eradication of this bacterium becomes more difficult as the prevalence \nof antibiotic resistance is increasing worldwide. Most H. pylori infections are now \ndiagnosed by non-invasive testing (i.e. urea breath test, serology, stool test), and thus data \non antibiotic susceptibility are lacking. Furthermore, once the antibiotic susceptibility is \nassessed using conventional culture-based methods by means of an E-test, agar dilution or \ndisc-diffusion, then data are difficult to compare between different centers due to lack of \nstandardization. Molecular-based methods are reproducible and easily standardized, and \nthus they can offer an attractive alternative. To develop molecular-based methods knowledge of molecular mechanisms underlying antibiotic resistance is mandatory. The research presented in this thesis aims to obtain information on molecular mechanisms of \nantibiotic resistance in H. pylori.
Author: Monique M. Gerrits
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: Stichting de Drie Lichten
OpenAlex ID: W1537381266