Work

Apolipoprotein A1-derived amyloid in human aortic atherosclerotic plaques.

Year: 1995

Type: article

Abstract: Amyloid deposits in the aortic intima are very common in association with atherosclerosis and aging. In the present study, a major fibril protein purified from amyloid present in human atherosclerotic plaques was shown to be a 69-amino acid N-terminal fragment of apolipoprotein AI. Although senile form of localized apolipoprotein AI-derived amyloidosis has recently been documented in pulmonary vessels of dogs, this is the first example of a localized human amyloid derived from this apolipoprotein.

Source: Europe PMC (PubMed Central)

Authors: P Westermark, G Mucchiano, T Marthin, K H Johnson, K Sletten

Institution: Linköping University

Language: English

Topic: Amyloidosis: Diagnosis, Treatment, Outcomes

Subfield: Internal Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1537453135

FWCI: 3.869

Cites: 17

Cited by: 112

Related to: 10