Work

Metastasectomy for gastrointestinal stromal tumors

Year: 2013

Type: review

Abstract: Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the intestinal tract. Improvements in understanding the molecular pathogenesis of GIST have resulted in novel treatment strategies combining surgery with tyrosine kinase inhibitors (TKIs). Metastasectomy in carefully selected patients who have stable or responsive disease on imatinib should be considered in the multidisciplinary setting. We review existing data on surgical cytoreduction in metastatic GIST while on targeted therapy and compare outcomes with either treatment alone.

Source: Journal of Surgical Oncology

DOI: 10.1002/jso.23451

Authors: Zubin M. Bamboat, Ronald P. DeMatteo

Institution: Memorial Sloan Kettering Cancer Center

Language: English

Topic: Gastrointestinal Tumor Research and Treatment

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute