Development of Curative Therapies for Ewing Sarcomas by Interdisciplinary Cooperative Groups in Europe
Year: 2015
Type: article
Abstract: Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70% in patients with localized disease. Translational research in ES remains an area in which interdisciplinary and international cooperation is essential for future progress. This article reviews current state-of-the art therapy, with a focus on trials performed in Europe, and summarizes novel strategies to further advance both the cure rates and quality of survival.
Source: Klinische Pädiatrie
Authors: T. Bölling, G. Braun-Munzinger, S. Burdach, G. Calaminus, A. Craft, O. Delattre, M.-C. Deley, U. Dirksen, B. Dockhorn-Dworniczak, J. Dunst, S. Engel, A. Faldum, B. Fröhlich, H. Gadner, U. Göbel, G. Gosheger, J. Hardes, D. Hawkins, L. Hjorth, C. Hoffmann, H. Kovar, J. Kruseova, R. Ladenstein, I. Leuschner, I. Lewis, O. Oberlin, M. Paulussen, J. Potratz, A. Ranft, C. Rössig, C. Rübe, R. Sauer, O. Schober, A. Schuck, B. Timmermann, F. Tirode, H. van den Berg, F. van Valen, V. Vieth, N. Willich, W. Winkelmann, J. Whelan, R. Womer
Institutions: University of Münster, University Hospital Münster, TUM Klinikum, Technical University of Munich, Royal Victoria Infirmary, Inserm, Institut Curie, Université Paris-Sud, Institut Gustave Roussy, University of Lübeck, St. Anna Children's Cancer Research Institute, Medical University of Vienna, Heinrich Heine University Düsseldorf, Seattle Children's Hospital, University of Washington, Fred Hutch Cancer Center, Lund University, Skåne University Hospital, Charles University, Christian-Albrechts-Universität zu Kiel, National Health Service, Alder Hey Children's NHS Foundation Trust, Witten/Herdecke University, Universitätsklinikum des Saarlandes, Saarland University, Friedrich-Alexander-Universität Erlangen-Nürnberg, Essen University Hospital, Amsterdam UMC Location University of Amsterdam, Emma Kinderziekenhuis, University of Amsterdam, UCL Biomedical Research Centre, University College London, Children's Hospital of Philadelphia, University of Pennsylvania
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1540788974