Work

Methods for olfactory fMRI studies: Implication of respiration

Year: 2013

Type: article

Abstract: Human olfactory system is under-studied using fMRI compared with other sensory systems. Because the perception (intensity, threshold, and valence) and detection of odors are tightly involved with respiration, the subject's respiration pattern modulates and interacts with the experimental paradigm, which presents difficulties for olfactory fMRI data acquisition, post-processing, and interpretation. Based on our investigation on the interactions of odor presentation and subject's respiration, we propose a respiration-triggered event-related olfactory fMRI technique and a data post-processing method that effectively captures precise onsets of olfactory blood-oxygen-level-dependent (BOLD) signal in the primary olfactory cortex. We compared the olfactory BOLD signals from seventeen normal healthy adults with diverse respiratory patterns and showed that the subjects' respiratory patterns modulated the olfactory stimulation paradigm, which significantly confounded the BOLD signal. The presented experimental technique provides a simple and effective means for generating reliable olfactory fMRI results.

Source: Human Brain Mapping

DOI: 10.1002/hbm.22425

Authors: Jianli Wang, Xiaoyu Sun, Qing X. Yang

Institutions: Pennsylvania State University, Penn State Milton S. Hershey Medical Center

Language: English

Topic: Olfactory and Sensory Function Studies

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging