Dietary Sodium Restriction Alters Postprandial Ghrelin: Implications for Race Differences in Obesity
Year: 2006
Type: article
Abstract: OBJECTIVES: To examine the effect of sodium restriction on the appetite-stimulating hormone, ghrelin, as a function of race, salt sensitivity, and obesity. DESIGN: PARTICIPANTS completed two 4-day outpatient dietary interventions (moderate vs low sodium), and blood samples were drawn two hours after a controlled test meal under both conditions. SETTING: A university research laboratory and affiliated General Clinical Research Center. PARTICIPANTS: 37 women (18 Black, 19 White) and 18 men (9 Black, 9 White), aged 36-63 years. MEASURES: Cardiovascular function (blood pressure, heart rate, impedance-derived indices of cardiac output and peripheral resistance) was measured after a 20-minute rest before each test meal. Blood was drawn by intravenous forearm catheter two hours after each test meal and later assayed for ghrelin, leptin, and norepinephrine. RESULTS: After four days of sodium restriction, postprandial ghrelin increased in White men and women and Black men but decreased in Black women. Salt sensitivity, but not obesity, was also related to ghrelin response during sodium restriction; postprandial ghrelin tended to increase among salt-sensitive subjects during salt restriction but decrease among salt-resistant subjects during salt restriction. CONCLUSIONS: Satiety hormone dysregulation may play a role in: 1) the heightened obesity-related morbidity among Black women, in particular; 2) adherence to sodium-restricted diets; and 3) race differences in behavioral weight-loss interventions that include sodium restriction.
Source: PubMed
DOI: 10.13016/midd-oypa
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1541126161