Mechanisms by Which Interleukin-4 Suppresses Inflammatory Cytokine Production by Activated Human Monocytes
Year: 2011
Type: dissertation
Abstract: Improving understanding of how inflammatory responses by monocytes and macrophages are regulated may aid in the development of more targeted therapies for chronic inflammatory disease.In this thesis the mechanisms by which the cytokine, IL-4, can suppress inflammatory cytokine production by LPS-stimulated human monocytes have been examined. IL-4 suppressed LPS-induced TNFα transcription, without inhibiting LPS signallingthrough IκB, the mitogen-activated protein kinase (MAPK) pathways, or LPSmediated activation of the transcription factor NF-κB. Histone acetylation regulated LPS-induced cytokine production but not the suppression of these cytokines by IL-4.IL-4 induced three molecules with potential anti-inflammatory properties, suppressor of cytokine signalling-1 (SOCS1), peroxisome proliferator-activated receptor gamma (PPARγ) and triggering receptors expressed on myeloid cells-2 (TREM-2), but suppressed LPS-induced TNFα production independently of these molecules.
Author: Eleanor Woodward
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Funder: Murdoch University
OpenAlex ID: W1541744429