Work

Novelly Synthesized Coumarin Derivative as a Pro-inflammatory Cytokines Inhibitor

Year: 2015

Type: article

Abstract: The purpose of this study was to investigate the effect of the novelly synthesized coumarin derivative, RKNU026 on pro-inflammatory cytokine inhibitory efficacy. The results demonstrated that RKNU026 could inhibit IL-1β and TNF-α production in a concentration dependent pattern. The half maximal inhibitory concentrations (IC50) of RKNU026 for IL-1β and TNF-α were 0.024 µM and 729 µM, respectively. Compared with dexamethasone at the same final concentration of 1 µM, the efficacy of RKNU026 on IL-1β inhibition was still lower than dexamethasone (70.78% versus 89.53%) while RKNU026 had no efficacy on TNF-α inhibition at this concentration. Our work suggests that RKNU026 has anti-inflammatory efficacy through pro-inflammatory cytokine inhibition. Furthermore, it is considered to be an IL-1β inhibitor rather than a TNF-α inhibitor.

Source: Journal of Basic and Applied Pharmacology

Authors: Prayuth Poowaruttanawiwit, Thippatai Hiranyaekaphap, Nanteetip Limpeanchob, Ruengwit Kitbunnadaj, Kwanchai Rattanamanee

Institution: Naresuan University

Language: Thai

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Higher Education Research Promotion, Thailand Research Fund, Naresuan University

OpenAlex ID: W1542512495

FWCI:

Cites: 29

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Related to: 10