Work

Cooperative Nanoparticles for Tumor Detection and Photothermally Triggered Drug Delivery

Year: 2009

Type: article

Abstract: A cooperative nanosystem consisting of two distinct nanomaterials works in vivo to detect tumor tissues and deliver drugs to the site. Gold nanorods (GNRs) localize to the tumor region, where they report their location and convert near-infrared radiation to thermal energy. Circulating thermally labile therapeutic liposomes respond to the thermal signal, releasing their drug payload selectively in the GNR-populated tumor.

Source: Advanced Materials

DOI: 10.1002/adma.200902895

Authors: Ji‐Ho Park, Geoffrey von Maltzahn, Luvena L. Ong, Andrea Centrone, T. Alan Hatton, Erkki Ruoslahti, Sangeeta N. Bhatia, Michael J. Sailor

Institutions: University of California San Diego, Howard Hughes Medical Institute, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, University of California, Santa Barbara

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute

Awards: Center of Nanotechnology for Treatment, Understanding, *, Engineering Multifunctional Nanoparticles, The MIT-Harvard Center of Cancer Nanotechnology Excelle*, G8453498386, G947370982

OpenAlex ID: W1542982772

FWCI: 9.229

Cites: 29

Cited by: 238

Related to: 10