Work

INSIG2 is Associated with Lower Gain in Weight-for-Length between Birth and Age 6 Months

Year: 2009

Type: article

Abstract: Researchers have described the association of a common DNA polymorphism, rs7566605, near INSIG2 (insulin-induced gene 2) with obesity in multiple independent populations that include subjects ages 11-60 years.1 To our knowledge, no studies have examined the association of this polymorphism with weight status during early childhood. We explored the association of the rs7566605 polymorphism with weight-for-length among 319 children at 6 months and 3 years participating in Project Viva, a pre-birth cohort study. In contrast to studies of older individuals, CC homozygosity was associated with lower gain in weight-for-length z-score between birth and age 6 months than GG homozygosity or GC heterozygosity. At age 3, we did not find an association. The association of INSIG2 gene with obesity may change direction with age.

Source: Clinical Medicine Insights Pediatrics

DOI: 10.4137/cmped.s2279

Authors: Ann Chen Wu, Matthew W. Gillman, Elsie M. Taveras, Augusto A. Litonjua

Institutions: Boston Children's Hospital, Harvard University, Harvard Pilgrim Health Care, Brigham and Women's Hospital

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,150