Year: 2015
Type: article
Abstract: We mainly discussed miR-#-5p and miR-#-3p under three aspects: (1) primary evolutionary analysis of human miRNAs; (2) evolutionary analysis of miRNAs from different arms across the typical 10 vertebrates; (3) expression pattern analysis of miRNAs at the miRNA/isomiR levels using public small RNA sequencing datasets. We found that no bias can be detected between the numbers of 5p-miRNA and 3p-miRNA, while miRNAs from miR-#-5p and miR-#-3p show variable nucleotide compositions. IsomiR expression profiles from the two arms are always stable, but isomiR expressions in diseased samples are prone to show larger degree of dispersion. miR-#-5p and miR-#-3p have relative independent evolution/expression patterns and datasets of target mRNAs, which might also contribute to the phenomena of arm selection and/or arm switching. Simultaneously, miRNA/isomiR expression profiles may be regulated via arm selection and/or arm switching, and the dynamic miRNAome and isomiRome will adapt to functional and/or evolutionary pressures. A comprehensive analysis and further experimental study at the miRNA/isomiR levels are quite necessary for miRNA study.
Source: BioMed Research International
DOI: 10.1155/2015/168358
Institutions: Nanjing Medical University, Dezhou University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,680
Awards: G106570729, G1359829750, G2304592622, G2375398136, G2839703102, G2914912094, G3253788909, G3351622663, G3472949501, G4254388419, G4291924288, G4421763859, G4585960705, G4995941332, G5099667266, G5289757390, G5517615404, G5610910513, G5625061447, G6070730250, G6543021786, G6548696129, G7189804241, G7204476199, miRNA序列多样性isomiR的生物学特点及功能研究, G7302040599, G8045639702, G995732258
OpenAlex ID: W1543931293