Work

Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics.

Year: 1983

Type: article

Abstract: The enzyme which confers resistance to erythromycin in the producing organism Streptomyces erythraeus dimethylates a single adenine residue in Bacillus stearothermophilus 23 S rRNA. This corresponds to residue Ade 2058 in Escherichia coli 23 S RNA. The methylase responsible for resistance to macrolides, lincomycin, and streptogramin B-related antibiotics in Staphylococcus aureus also acts at this site.

Source: Journal of Biological Chemistry

DOI: 10.1016/s0021-9258(17)44232-3

Authors: R Skinner, E Cundliffe, F J Schmidt

Institutions: University of Leicester, University of Missouri

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

OpenAlex ID: W1544330746

FWCI: 3.873

Cites: 24

Cited by: 269

Related to: 10