Work

Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs

Year: 1996

Type: review

Abstract: Recent experimental work has shown that the mitogen-activated protein (MAP) kinase cascade can convert graded inputs into switch-like outputs. The cascade could therefore filter out noise (signals of insufficient magnitude or duration) and still respond decisively to supra-threshold stimuli. Here, we explore the biochemical mechanisms likely to be at the root of this behavior.

Source: Trends in Biochemical Sciences

DOI: 10.1016/s0968-0004(96)20026-x

Author: James E. Ferrell

Institutions: Stanford Medicine, Stanford University

Language: English

Topic: Gene Regulatory Network Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $7,030

Funders: National Institutes of Health, National Institute of General Medical Sciences