Cellular Responses to Replication Problems
Year: 2008
Type: dissertation
Abstract: During every S-phase cells need to duplicate their genomes so that both\ndaughter cells inherit complete copies of genetic information. It is a tremendous task,\ngiven the large sizes of mammalian genomes and the required precision of DNA\nreplication. A major threat to the accuracy and efficiency of DNA synthesis is the\npresence of damaged DNA, e.g. abasic sites, single stranded DNA breaks, DNA\ncrosslinks and adducts. This damage can be caused by exogenous agen
Author: Magdalena Budzowska
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1544928824