Year: 2014
Type: article
Abstract: OBJECTIVE: Determine objective measures of kidney function and analyze factors associated with kidney dysfunction in severely obese adolescents undergoing weight loss surgery were described. METHODS: Cross-sectional data from 242 adolescent participants in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study before weight loss surgery were analyzed. Kidney status was assessed by measuring urine albumin creatinine ratio to determine microalbuminuria and by calculating serum cystatin C-based estimated glomerular filtration rate (eGFR) to assess kidney function. RESULTS: Mean age and median body mass index (BMI) were 17.1 years and 50.5 kg/m(2) , respectively; 76% were females and 65% were non-Hispanic white race. Fourteen percent of the cohort had microalbuminuria, and 3% had macroalbuminuria; 3% had eGFR < 60 ml/min/1.73 m(2) , and 7.1% had eGFR > 150 ml/min/1.73 m(2) . In adjusted analyses, female gender and increasing ferritin levels were significantly associated with the presence of microalbuminuria/macroalbuminuria. Increasing BMI and homeostasis model assessment of insulin resistance values were significantly associated with lower eGFR. CONCLUSIONS: A significant number of severely obese adolescents undergoing weight loss surgery have evidence of early kidney dysfunction. Longitudinal studies following weight loss surgery in these individuals are needed to determine whether these kidney abnormalities are reversible following weight loss therapy.
Source: Obesity
DOI: 10.1002/oby.20870
Institutions: Cincinnati Children's Hospital Medical Center, Nationwide Children's Hospital, University at Buffalo, State University of New York, Texas Children's Hospital, University of Pittsburgh Medical Center, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Texas Children's Hospital, Cincinnati Children's Hospital Medical Center, Nationwide Children's Hospital, University of Pittsburgh, University of Cincinnati, University of Alabama at Birmingham, University of Alabama, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: G1037376802, G1650250266, Continuation of Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS), Biostatistics Research Center, G2420531979, The Ohio State University Center for Clinical and Translational Science (UL1), G2707217263, University of Pittsburgh Clinical and Translational Science Institute, G3791567531, The Ohio State University Center for clinical and Translational Science, G4821685324, Teen Longitudinal Assessment of Bariatric Surgery (Teen LABS) Research Project, G517149770, Center for Clinical and Translational Science and Training, University of Pittsburgh Clinical and Translational Science Institute, General Clinical Research Center, G7071477249, G71706220, Adolescent Bariatrics: Assessing Health Benefits & Risks, G7366577937, Cardiovascular Disease in Children with Chronic Kidney Disease, G8232721138, Cincinnati Center for Clinical and Translational Sciences and Training
OpenAlex ID: W1545114786