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Diphtheria Toxin-dependent Adenosine Diphosphate Ribosylation of Aminoacyl Transferase II and Inhibition of Protein Synthesis

Year: 1968

Type: article

Abstract: In the presence of diphtheria toxin, the adenosine diphosphate ribose portion of nicotinamide adenine dinucleotide was transferred to aminoacyl transferase II obtained from rat liver. The reaction resulted in a concurrent inactivation of this particular enzyme, one of the supernatant factors which assemble amino acids into polypeptide chain. The linkage of ADP-ribose to aminoacyl transferase II appeared to be of covalent nature. The reaction was reversible. Diptheria toxin may act as an enzyme or a catalytic cofactor in this reaction.

Source: Journal of Biological Chemistry

DOI: 10.1016/s0021-9258(18)93347-8

Authors: T Honjo, Y Nishizuka, O Hayaishi, I Kato

Institutions: Kyoto University, Institute of Medical Science, The University of Tokyo, The University of Tokyo

Language: English

Topic: Toxin Mechanisms and Immunotoxins

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

OpenAlex ID: W1545162664

FWCI: 10.62

Cites: 11

Cited by: 540

Related to: 10