Homeostasis as Regulated by Activated Macrophage. VI. Protective Effect of LPSw (a Lipopolysaccharide from Wheat Flour) against Acute Infection by Toxoplasma gondii in Mice.
Year: 1992
Type: article
Abstract: An oral administration of partially purified LPSw, a lipopolysaccharide (LPS) from wheat flour, at a concentration of 20 ng/ml in drinking water beginning 1d after infection significantly decreased mouse mortality and prevented animal weight loss in acute infection with Toxoplasma gondii. Whereas 71% (5/7) of mice in a control group that did not receive LPSw died of toxoplasmosis, only 14% (1/7) of mice treated with LPSw died (p less than 0.05). The administration of LPS purified from Bordetella pertussis also significantly decreased the mortality of infected mice. LPS from Escherichia coli and synthetic lipid A (LA-15-PP(506)), however, did not show a significant decrease in mortality.
DOI: 10.1248/cpb.40.1266
Authors: Yasuhiro SUZUKI, Akio KOBAYASHI, Takashi NISHIZAWA, Hiroyuki INAGAWA, Akinobu MORIKAWA, Gen-Ichiro SOMA, Den'ichi MIZUNO
Institution: Jikei University School of Medicine
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1545689260