Work

Structural biology of the IL‐1 superfamily: Key cytokines in the regulation of immune and inflammatory responses

Year: 2014

Type: review

Abstract: Interleukin-1 superfamily of cytokines (IL-1, IL-18, IL-33) play key roles in inflammation and regulating immunity. The mechanisms of agonism and antagonism in the IL-1 superfamily have been pursued by structural biologists for nearly 20 years. New insights into these mechanisms were recently provided by the crystal structures of the ternary complexes of IL-1β and its receptors. We will review here the structural biology related to receptor recognition by IL-1 superfamily cytokines and the regulation of its cytokine activities by antagonists.

Source: Protein Science

DOI: 10.1002/pro.2441

Authors: Brian Krumm, Yan Xiang, Junpeng Deng

Institutions: Oklahoma State University, The University of Texas at San Antonio Health Science Center

Language: English

Topic: Cytokine Signaling Pathways and Interactions

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: bronze

Funders: Oklahoma State University, National Institutes of Health, Oklahoma Agricultural Experiment Station, National Institute of Allergy and Infectious Diseases

Awards: Poxvirus Immune Evasion Mechanisms, Structure-function studies on IL-18, IL-18 binding proteins and receptors