Work

Discovering the genetic determinants of complex diseases

Year: 2009

Type: article

Abstract: Common diseases have a multifactorial etiology and understanding their causation will have a major impact on public health. However, the enormous diversity within complex traits, not only in their environmental determinants but also in their genetic components of risk, means specific genetic variants causally associated with common diseases will have small effects, and their identification so far has been an uphill struggle. Emerging technologies are now allowing researchers to study hundreds of thousands of genetic variants as risk factors for common complex diseases, with promising and exciting results. However, there are a number of challenges, including optimal study designs, population stratification, multiple testing, environment and gene interactions, and the effect of epigenetics and structural chromosomal variations.

Source: Research Portal (King's College London)

Authors: Sandosh Padmanabhan, Cristina Menni, Dorairaj Prabhakaran, Anna F. Dominiczak

Institution: University of Glasgow

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1547709071

FWCI: 0.297

Cites: 65

Cited by: 3

Related to: 10