Year: 2014
Type: article
Study design: Observational Study
Abstract: Tumor biopsy is rarely performed in diffuse intrinsic pontine glioma (DIPG) due to the presumed risk of surgical complications, although data on the surgery related morbidity of DIPG biopsy is sparse. We performed a retrospective review on 22 consecutive cases of DIPG diagnosed from 2002 to 2012 at Children's Hospital of Michigan, 15 of which underwent biopsy. Transient new or worsening neurological deficits were observed in three of 15 cases following surgery. No surgery related mortality or permanent deficit was observed, and the mean overall survival was 10.4 ± 3.8 months. Undergoing biopsy did not adversely affect the outcome.
Source: Pediatric Blood & Cancer
DOI: 10.1002/pbc.25224
Authors: Zhihong J. Wang, Latha Rao, Kanta Bhambhani, Kathy Miller, Janet Poulik, Deniz Altinok, Sandeep Sood
Institutions: Wayne State University, Children's Hospital of Michigan
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1547846010