Work

Matrix Metalloproteinase’s Role in Producing and Curing of Liver Fibrosis

Year: 2009

Type: article

Abstract: Matrix metalloproteinases are a zinc and calcium dependent endopeptidase family that areexpressed in injured tissue such as cardiovascular or hepatic disease. Complex efforts of thisenzymes on the extra cellular matrix structure is related to up and down regulation of themand their tissue inhibitors. Configuration of extra cellular matrix during pathogenesis, curingand development is affected by two key mechanisms: matrix metalloproteinase and hepaticstellate cell activity. The important role of these enzymes on liver injuries and regenerationare indicated when their effects on migration of bone marrow stem cells and hepatic stemcells was discoverd.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

Authors: Hossein Baharvand, Vahideh Rabani

Language: English

Topic: Liver physiology and pathology

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1547966890

FWCI: 0.194

Cites: 101

Cited by: 1

Related to: 10