Human Tubular Epithelial Cells and T-cell Alloreactivity
Year: 2014
Type: dissertation
Abstract: __Abstract__ \n \nKidney transplantation is the treatment of choice for patients with end-stage renal disease. The \nfirst successful transplantation was performed in 1954 and acceptable renal allograft survival was \nachieved after introduction of azathioporine in combination with high dose of corticosteroids in the \nmid sixties of the 20th century. Introduction of the immunosuppressant calcineurin inhibitor \n(CNI) cyclosporin A and later on tacrolimus significantly improved the outcome of kidney graft \nsurvival. Tacrolimus compared to cyclosporin diminished the acute rejection rate by 31% during \nthe first year after transplantation, and this percentage was even more reduced using anti-CD25 \nmAb as induction treatment [5]. This success have shifted the problem of transplantation from short \nterm graft survival to how to improve the long term graft survival. The 5-year allograft survival rate \nin the Netherlands is 83% for deceased donor kidneys and 92% for living donor kidney transplants \n(Nederlandse Transplantatie Stichting, 12th August 2013). In contrast, the overall European 5-year \ngraft survival is 77% and the USA 5-year graft survival is even worse, representing only 71% graft \nsurvival.
Author: Martijn W.H.J. Demmers
Language: English
Subfield: Transplantation
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W154872561