Epigenetic alterations in metastatic cutaneous carcinoma
Year: 2014
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are the 2 most common cutaneous carcinomas. Molecular profiles predicting metastasis of these cancers have not been identified. METHODS: Epigenetic profiles of 37 primary cases of cutaneous SCC and BCC were quantified via the Illumina Goldengate Cancer Panel. Differential protein expression by metastatic potential was analyzed in 110 total cases by immunohistochemical (IHC) staining. RESULTS: Unsupervised hierarchical clustering analysis revealed that metastatic BCCs had a methylation profile resembling cutaneous SCCs. Metastatic cutaneous SCCs were found to be hypermethylated at FRZB (median methylation: 46.7% vs 4.7%; p = 4 × 10(-5) ). Metastatic BCCs were found to be hypomethylated at MYCL2 (median methylation: 3.8% vs 83.4%; p = 1.9 × 10(-6) ). Immunohistochemical staining revealed few differences between metastatic and nonmetastatic cancers. CONCLUSION: Metastatic primary BCCs and cutaneous SCCs had distinct epigenetic profiles when compared to their nonmetastatic counterparts. Epigenetic profiling may prove useful in future diagnosis and prevention of advanced nonmelanoma skin cancers.
Source: Head & Neck
DOI: 10.1002/hed.23701
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1421429495, Environmental Toxicology and Epidemiology Pre- and Post-Doctoral Research T32 Training Program, The Molecular Basis of Head and Neck Cancer Biology, Treatment and Prevention, G590700339, Integrative epigenomic/genomic profiling and biomarker discovery in HPV+ and HPV-, University of Michigan Training Program in Genomic Science, Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)
OpenAlex ID: W1548824696