Work

Methamphetamine and the hypothalamic-pituitary-adrenal axis

Year: 2015

Type: article

Abstract: Psychostimulants such as methamphetamine (MA) induce significant alterations in the function of the hypothalamic-pituitary-adrenal (HPA) axis. These changes in HPA axis function are associated with altered stress-related behaviors and might contribute to addictive processes such as relapse. In this mini-review we discuss acute and chronic effects of MA (adult and developmental exposure) on the HPA axis, including effects on HPA axis associated genes/proteins, brain regions, and behaviors such as anxiety and depression. A better understanding of the mechanisms through which MA affects the HPA axis may lead to more effective treatment strategies for MA addiction.

Source: Frontiers in Neuroscience

DOI: 10.3389/fnins.2015.00178

Authors: Damian G. Zuloaga, Jason S. Jacosbskind, Jacob Raber

Institutions: University at Albany, State University of New York, Oregon National Primate Research Center, Oregon Health & Science University

Language: English

Topic: Stress Responses and Cortisol

Subfield: Behavioral Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801