Year: 2003
Type: article
Study design: Observational Study
Abstract: BACKGROUND: In experimental ageing models an inverse relationship between age and alkaline phosphatase activity has been observed. OBJECTIVE: To characterize serum levels of alkaline phosphatase activity in humans according to age and gender. METHODS: Serum alkaline phosphatase was determined in a random sample of 203 community dwellers aged 40 or more years. RESULTS: In men (n=87) total serum alkaline phosphatase markedly increased from the 5th to the 6th decade and then stabilized. For women (n=116) there was a slight increase in total serum alkaline phosphatase from the 5th to the 6th decade, followed by a bend upward after 69 years of age. There was a significant positive correlation between total serum alkaline phosphatase and age for the whole population. CONCLUSIONS: Serum alkaline phosphatase activity appears as a biomarker of age in humans, similarly to what has been described for experimental animal models.
Source: PubMed
Authors: M R Negrão, M J Martins, E Ramos, H Barros, C Hipólito-Reis, I Azevedo
Institution: Universidade do Porto
Language: Portuguese
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W155129271