Atividade moduladora de extratos etanólico e hexânico de raiz de Costus cf. arabicus sobre drogas antimicrobianas
Year: 2013
Type: article
Abstract: The bacterium Escherichia coli is known to produce enterotoxins causing diarrheal diseases. Some species of Staphylococcus are recognized as etiological agents of many animal and human opportunistic infections. Pseudomonas aeruginosa is the main cause of nosocomial infections, mainly affecting immunocompromised patients. Candidiasis is the most frequent opportunistic mycosis, frequently caused by Candida albicans, C. tropicalis, C. parapsilosis, C. glabrata, and C. krusei. Medicinal plants have been the source of many remedies used in the clinical practice. In this study, the hexane and methanol extracts of Costus cf. arabicus were assayed to the antibacterial activity alone or associated with aminoglycosides and antifungal drugs. Synergism of the ethanol and hexane were verified by the microdilution method. A synergistic effect of the two extracts combined with the aminoglycosides and antifungal agents was demonstrated. It is therefore suggested that the extracts from Costus cf. arabicus could be used as a source of natural products with resistance-modifying antimicrobial activity, providing a new mechanism against the problem of bacterial and fungal resistance to drugs.
Authors: Saulo Relison Tintino, Francisco Assis Bezerra da Cunha, Karla K.A. Santos, Gláucia Morgana de Melo Guedes, Celestina Elba Sobral de Souza, Edinardo Fágner Ferreira Matias, Maria Flaviana Bezerra Morais‐Braga, Jaqueline Cosme Andrade, José Galberto Martins da Costa, Maria Audilene de Freitas, Henrique Douglas Melo Coutinho
Language: Portuguese
Subfield: Food Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W1551655295