Induction of alpha interferon by human immunodeficiency virus type 1 in human monocyte-macrophage cultures
Year: 1991
Type: article
Abstract: The induction of interferon (IFN) by human immunodeficiency virus type 1 (HIV-1) in primary, nonstimulated monocyte-macrophage cultures was studied. HIV-1 infection, as confirmed by p24 antigen levels in the cell supernatant, led to the production of alpha interferon (IFN-alpha) over 7 to 21 days following infection. In two of seven experiments, the IFN detected was acid labile. Coupled reverse transcription-polymerase chain reaction analysis confirmed the induction of IFN-alpha mRNA in cells of HIV-1-infected cultures.
Source: Journal of Virology
Authors: J Szebeni, C Dieffenbach, S M Wahl, C N Venkateshan, A Yeh, M Popovic, S Gartner, L M Wahl, M Peterfy, R M Friedman
Institution: National Cancer Institute
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1551850966