Work

The Brain's Aging Immune System.

Year: 2010

Type: article

Abstract: In this review, we summarize key observations supporting the idea of immunosenescence in the CNS. We provide a discussion of senescent changes that affect microglial cells and emphasize differences between laboratory rodents and humans. Microglial immunosenescence may explain why humans but not rodents develop neurofibrillary degeneration.

Source: PubMed Central

Authors: Wolfgang J Streit, Qing-Shan Xue

Institution: University of Florida

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute on Aging

Award: Microglial Dysfunction in Aged and Alzheimers's Brain