Work

Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice

Year: 2000

Type: article

Abstract: Members of the Mycobacterium tuberculosis group synthesize a family of long-chain fatty acids, mycolic acids, which are located in the cell envelope. These include the non-oxygenated alpha-mycolic acid and the oxygenated keto- and methoxymycolic acids. The function in bacterial virulence, if any, of these various types of mycolic acids is unknown. We have constructed a mutant strain of M. tuberculosis with an inactivated hma (cmaA, mma4) gene; this mutant strain no longer synthesizes oxygenated mycolic acids, has profound alterations in its envelope permeability and is attenuated in mice.

Source: Molecular Microbiology

DOI: 10.1046/j.1365-2958.2000.01882.x