Hepatic liposis and myocardial damage in mice fed choline-deficient or choline-supplemented diets.
Year: 1960
Type: article
Abstract: The feeding of hypolipotrophic diets produces rapid and extensive hepatic liposis in several species including rats4 and mice.2" ' In addition to being deficient in choline the diets used in such experiments usually contain a large amount of fat and a marginal amount of protein.'18 Hypertension and renal glomerular lesions have been observed in rats fed such diets.' These observations have stimulated study of the actions of this type of nutritional deficiency in the production of lesions of arteries and myocardium.5"' 7 There are contradictions related to the specific actions of the choline deficiency in several aspects of experimentally produced cardiovascular disease including injury to the heart and blood vessels,17 "" " and plasma levels of lipids and lipoproteins. ' In the present study major attention has been directed to hepatic liposis and to myocardial necrosis and fibrosis in young adult mice. The mice were older than the rats commonly used in such experiments. The selection of older animals was intentional so that a postweaning phase (four to six
Source: PubMed Central
Author: W L WILLIAMS
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1553188325