Work

Surfactant Protein D Enhances Clearance of Influenza A Virus from the Lung In Vivo

Year: 2001

Type: article

Abstract: Mice lacking surfactant protein surfactant protein D (SP-D(-/-)) and wild-type mice (SP-D(+/+)) were infected with influenza A virus (IAV) by intranasal instillation. IAV infection increased the endogenous SP-D concentration in wild-type mice. SP-D-deficient mice showed decreased viral clearance of the Phil/82 strain of IAV and increased production of inflammatory cytokines in response to viral challenge. However, the less glycosylated strain of IAV, Mem/71, which is relatively resistant to SP-D in vitro, was cleared efficiently from the lungs of SP-D(-/-) mice. Viral clearance of the Phil/82 strain of IAV and the cytokine response were both normalized by the coadministration of recombinant SP-D. Since the airway is the usual portal of entry for influenza A virus and other respiratory pathogens, SP-D is likely to play an important role in innate defense responses to IAV.

Source: The Journal of Immunology

DOI: 10.4049/jimmunol.167.10.5868

Authors: Ann Marie LeVine, Jeffrey A Whitsett, Kevan L Hartshorn, Erika C Crouch, Thomas R Korfhagen

Institutions: Cincinnati Children's Hospital Medical Center, Boston University, Washington University in St. Louis

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute