Protein toxicity in Kotri Paint industry workers exposed to Phthalic Anyhydride and Trimellitic Anyhydride
Year: 2014
Type: article
Study design: Observational Study
Abstract: Background: Protein plays a significant role in the regulation of metabolism for normal functioning in human body. SITE area, Kotri paint industry workers are at high risk of hypersensitivity, sensitization of the respiratory tract (including asthma), skin diseases and allergy. Reactive Low molecular weight organic acid anhydrides (OAAs) like trimelitic anhydride (TMA) and phthalic anhydride (PA) are extensively used in local paint industries of SITE AREA, Kotri, Sindh – Pakistan. These both anhydrides may easily bind with high molecular weight proteins by forming complex (adducts) leading to metabolic disorders among the exposed workers. Methods : There is no study to differentiate protein status of workers compared with normal healthy group as compare in the past. In this regard, the total protein was determined in intravenous blood samples obtained from the exposed workers to TMA and PA with control group clinically by Microlab300 (Kit Method System). Result: There is a significant decrease of protein level in paint industry workers as compared with healthy subjects, which never had exposed to TMA and PA. Conclusion: These both allergenic organic acid anhydrides like TMA and PA may be associated for changing protein function status after forming complex (adduct) by long exposure at work. SITE Area, Kotri Paint workers may at high risk of asthma, exposed to TMA and PA.
Authors: Sumera Qureshi, Allah Bux Ghanghro, Shaista Khan, Ambreen Shah
Institution: University of Sindh
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1553821513