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Potassium channels from NG108‐15 neuroblastoma‐glioma hybrid cells: Primary structure and functional expression from cDNAs

Year: 1989

Type: article

Abstract: The complete amino acid sequences of two potassium channel proteins from NG108-15 neuroblastoma-glioma hybrid cells have been deduced by cloning and sequencing the cDNAs. One of these proteins (NGK2) is structurally more closely related to the Drosophila Shaw gene product than to the Shaker and Shab gene products, whereas the other (NGK1) is identical with a rat brain potassium channel protein (BK2) which is more closely related to the Drosophila Shaker gene product. mRNAs derived from both the cloned cDNAs, when injected into Xenopus oocytes, direct the formation of functional potassium channels with properties of delayed rectifiers.

Source: FEBS Letters

DOI: 10.1016/0014-5793(89)81488-7

Authors: Shigeru Yokoyama, Keiji Imoto, Tetsuro Kawamura, Haruhiro Higashida, Naoyuki Iwabe, Takashi Miyata, Shosaku Numa

Institutions: Kanazawa University, Kyoto University, Kyushu University

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Mitsubishi Foundation, Japan Heart Foundation

OpenAlex ID: W1557172174

FWCI: 7.753

Cites: 32

Cited by: 189

Related to: 10