Work

cis- and trans-acting regulation of gene expression of equine infectious anemia virus

Year: 1988

Type: article

Abstract: Deletion analysis of the equine infectious anemia virus long terminal repeat revealed that sequences responsive to virus-specific transactivation are located within the region spanning the transcriptional start site (-31 to +22). In addition, an active exon of a trans-acting factor (tat) was identified downstream of pol and overlapping env (nucleotides 5264 to 5461). Activation by tat is accompanied by an increase in the steady-state levels of mRNA directed by the equine infectious anemia virus long terminal repeat.

Source: Journal of Virology

DOI: 10.1128/jvi.62.9.3522-3526.1988

Authors: P L Dorn, D Derse

Institutions: Frederick National Laboratory for Cancer Research, National Cancer Institute

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute

Awards: OPERATIONS AND TECHNICAL SUPPORT, G2246755306