Year: 2013
Type: article
Abstract: Currently only about 8% of the new molecules have both high solubility and permeability. The drugs therapeutic efficacy depends upon the bioavailability and ultimately upon the solubility. Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge due to solubility problems. Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include nanonization, sonocrystallization, micronization, supercritical fluid method, spray freezing into liquid and lyophilization, evaporative precipitation into aqueous solution, use of surfactant, use of salt forms, solvent deposition, use of co-solvent, hydrotropy method, solubilizing agents, modification of the crystal habit, co-crystallisation, complexation and drug dispersion in carriers. Among several methods, solid dispersion has attracted attention of the researchers for previous 50 years. The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic inert carrier or matrix and a hydrophobic drug. KEY-WORDS: Solid dispersion, Solubility, Carrier, Drug
Author: Patel Chirag J
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W1558137626