Work

Gene-environment interactions in mental disorders.

Year: 2004

Type: article

Abstract: Research clearly shows that both nature and nurture play important roles in the genesis of psychopathology. In this paper, we focus on 'gene-environment interaction' in mental disorders, using genetic control of sensitivity to the environment as our definition of that term. We begin with an examination of methodological issues involving gene-environment interactions, with examples concerning psychiatric and neurological conditions. Then we review the interactions in psychiatric disorders using twin, adoption and association designs. Finally, we consider gene-environment interactions in selected neurodevelopmental disorders (autism and schizophrenia).

Source: Europe PMC (PubMed Central)

Authors: Ming T Tsuang, Jessica L Bar, William S Stone, Stephen V Faraone

Institutions: Harvard University, Massachusetts Mental Health Center

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Mental Health, National Institute on Drug Abuse

Awards: MOLECULAR GENETICS OF HEROIN DEPENDENCE, NEURODEVELOPMENTAL STUDY OF SCHIZOPHRENIA--PHASE III, Training in Psychiatric Genetics