Homocysteine and cardiovascular disease: should we treat?
Year: 2008
Type: article
Abstract: Homocysteine was first discovered over seventy years ago and has attracted the interest of researchers ever since.1 The small, sulfur-containing, non-protein-forming amino acid is a key intermediate in the methylation cycle and is produced by all cells during the metabolism of methionine. Excess intracellular homocysteine is exported to the circulation where approximately 1% remains in a free form and the remainder binds to albumin or forms disulfide dimers, principally with cysteine.2 Total plasma homocysteine (tHcy) is measured as the combined pool of all these forms and has been linked with several diseases. However, it is the relationship between tHcy and cardiovascular disease that has received most attention in the last few decades.
Source: PubMed
Author: Kathleen Potter
Institution: The University of Western Australia
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1561390415