Novel functions of the Neurofibromatosis 2 tumour suppressor protein merlin
Year: 2005
Type: dissertation
Abstract: 9 REVIEW OF THE LITERATURE 11 1. THE CELL DIVISION CYCLE 11 2. CANCER GENES 12 2.1 Oncogenes 12 2.2 Tumour suppressor genes 13 3. THE ACTIN CYTOSKELETON 13 3.1 The actin cytoskeleton in disease 14 4. THE BAND 4.1 PROTEIN SUPERFAMILY 14 4.1 The ERM protein family 15 4.1.1 The ERM proteins 16 4.1.1.1 Structure of the ERM proteins 17 4.1.2 The NF2 protein, merlin 17 4.1.3 Ezrin and merlin in neoplasia 19 4.1.3.1 Neurofibromatosis 2, NF2 19 5. MOLECULAR INTERACTIONS AND FUNCTIONS OF MERLIN AND EZRIN 20 5.1 Association with the cytoskeleton 20 5.2 Association with the plasma membrane 22 5.3 Cell adhesion and cell-cell communication 23 5.4 Cell proliferation 24 6. REGULATION OF MERLIN AND EZRIN 26 6.1 Phosphorylation 26 6.2 RHO GTPases 29 6.3 Homotypic and heterotypic binding 30 6.4 Other mechanisms of regulation 30 AIMS OF THE STUDY 32 METHODS 33 RESULTS AND DISCUSSION 34 1. HETEROTYPIC AND HOMOTYPIC INTERACTIONS OF MERLIN AND EZRIN (I) .......34 1.1 Heterotypic interactions 34 1.2 Homotypic interactions 35 1.3 Merlin N-ERMAD and C-ERMAD 36 1.4 Regulation of the dormant and active states 37
Source: Työväentutkimus Vuosikirja
Author: Mikaela Grönholm
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1562014531