Year: 2008
Type: dissertation
Abstract: Several psychiatric disorders in childhood and adulthood have been hypothesized to be\nneurodevelopmental in origin. Numerous studies have provided evidence for subtle deviations\nin brain morphology in children and adults with attention-defi cit hyperactivity disorder,\nautism spectrum disorders, and schizophrenia, compared to healthy children and adults. It is\nstill unclear whether these subtle changes emerge in prenatal life or during brain maturation\nin childhood and adolescence. Findings supporting the hypothesis that (child) psychiatric\ndisorders are related to an adverse environment in fetal life and early postnatal life include\nincreased risk for schizophrenia in persons born after exposure to severe famine in utero\nand increased frequency of obstetric complications in patients with neurodevelopmental\ndisorders.\nThis thesis aimed to extend existing knowledge on the prenatal and early neurodevelopmental\nbasis of behavioral and emotional problems. The studies in this thesis were conducted\nin the Generation R Study, a data collection project from fetal life until young adulthood in\nRotterdam, the Netherlands.
Author: Sabine J. Roza
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1562357498