Year: 2004
Type: dissertation
Abstract: Hypertension, or elevated arterial blood pressure is a substantial public health problem, \naffecting about 25 % of the adult population. This disorder is a major risk factor for common causes of morbidity and mortality including stroke, myocardial infarction, heart \nfailure, and end-stage renal disease. Despite the morbid consequences of hypertension, \nits pathogenesis remains to be fully elucidated. Difficulties in defining the causes of \nhypertension from physiological studies alone have motivated studies to search for genetic factors in the etiology of hypertension. Identification of genes influencing blood \npressure variation may confer more insight into the physiological mechanisms \nunderlying blood pressure variation and reveal pathways and targets for therapeutical \nintervention. In recent years, several genes responsible for rare Mendelian forms of \nhypertension have been identified.
Author: Anna FC Schut
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1562466643