Work

Otx2-PNN Interaction to Regulate Cortical Plasticity

Year: 2016

Type: review

Abstract: The ability of the environment to shape cortical function is at its highest during critical periods of postnatal development. In the visual cortex, critical period onset is triggered by the maturation of parvalbumin inhibitory interneurons, which gradually become surrounded by a specialized glycosaminoglycan-rich extracellular matrix: the perineuronal nets. Among the identified factors regulating cortical plasticity in the visual cortex, extracortical homeoprotein Otx2 is transferred specifically into parvalbumin interneurons and this transfer regulates both the onset and the closure of the critical period of plasticity for binocular vision. Here, we review the interaction between the complex sugars of the perineuronal nets and homeoprotein Otx2 and how this interaction regulates cortical plasticity during critical period and in adulthood.

Source: Neural Plasticity

DOI: 10.1155/2016/7931693

Authors: Clémence Bernard, Alain Prochiantz

Institutions: Centre National de la Recherche Scientifique, Inserm, Collège de France, Centre Interdisciplinaire de Recherche en Biologie

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,830

Funders: Agence Nationale de la Recherche, FP7 Ideas: European Research Council