Work

Single-molecule Enzymology

Year: 1999

Type: review

Abstract: Viewing a movie of an enzyme molecule made by molecular dynamics simulation, we see incredible details of molecular motions, be they changes of the conformation or actions during a chemical reaction. Molecular dynamics simulations have advanced our understanding of the dynamics of macromolecules in ways that would not be deducible from the static crystal structures (for review see Refs. 1 and 2). Unfortunately, these “virtual movies” do not run long enough compared with the time scale of milliseconds to seconds in which most enzymatic reactions take place.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.274.23.15967

Authors: X. Sunney Xie, H. Peter Lu

Institutions: Pacific Northwest National Laboratory, Environmental Molecular Sciences Laboratory

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

OpenAlex ID: W1563322259

FWCI: 1.057

Cites: 62

Cited by: 266

Related to: 9