Aspects of endothelial function testing in coronary vascular disease
Year: 2003
Type: dissertation
Abstract: BACKGROUND AND METHODS In 8 patients without coronary artery disease (controls) and in 6 patients with coronary artery disease coronary flow velocity and cardiac output were measured continuously. The effect of activation of the autonomic nervous system with the cold pressor test and the diving test were compared. RESULTS The effect of the cold pressor test, the diving test and intracoronary papaverine were highly reproducible. The cold pressor test did not affect coronary resistance in the control group and caused an increased resistance in the coronary artery disease group. The changes in coronary resistance during the diving test and papaverine were comparable between the groups. In patients with normal coronary arteries, the diving test more so than the cold pressor test further differentiated between patients with a normal and abnormal PET scan. CONCLUSIONS We conclude that the effects of the cold pressor test and the diving test on coronary and systemic hemodynamics can simultaneously be measured. Differences in response to autonomic activation between the control group and the coronary artery disease group were most pronounced during the cold pressor test. For further differentiation into subgroups the diving test can be useful.
Author: Stefan H.J. Monnink
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1565002426