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Bone tissue: hormonal regulating systems, growth factors and remodeling as a target for therapeutic agents in osteoporosis

Year: 2012

Type: article

Abstract: Bone regulating systems have received growing attention in recent years. Regulation of skeletal pathophysiology and modulation of osteoblast, osteoclast and osteocyte activity by hormones, cytokines, and growth factors are not only important features of bone biology, but also a target for old and new osteoporosis therapies. \nMolecules such as selective estrogen receptor modulators (SERMs, e.g. raloxifene and bazedoxifene), denosumab, or bisphosphonates may exert their effects through modulation of estrogen receptor, RANKL and osteoclast activity, respectively. Knowledge of the regulating systems is also the basis for developing future therapy. This review shows regulating systems as a basis for current and future therapies in the field of osteoporosis

Source: CNR Solar (Scientific Open-access Literature Archive and Repository) (Consiglio Nazionale delle Ricerche)

Authors: Stefano Lello, Francesca Guardianelli, Luciana Mosca

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1565668056

FWCI:

Cites: 26

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Related to: 10