Work

Unraveling the therapeutic potential of the LncRNA-dependent noncanonical Hedgehog pathway in cancer

Year: 2015

Type: article

Abstract: Acquired resistance to Hedgehog pathway inhibitors has been reported in the clinical setting and upregulation of noncanonical Hedgehog signaling is one of the major underlying mechanisms behind this resistance. As demonstrated in our recent study, greater clinical efficacy might be achieved by focusing on downstream targets of the chemokine-activated noncanonical Hedgehog signaling pathway such as BCAR4 and phospho-GLI2 (Ser149).

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2014.998900

Authors: Zhen Xing, Chunru Lin, Liuqing Yang

Institution: The University of Texas MD Anderson Cancer Center

Language: English

Topic: Hedgehog Signaling Pathway Studies

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,590