Year: 2006
Type: article
Abstract: Introduction: Significant research exists to support the use of omega-3 fatty acids in the primary prevention of coronary heart disease (CHD); however few studies exist to support the use of omega-3 fatty acids in those patients already diagnosed with CHD.This study aims to investigate the cardioprotective benefits of dietary and non-dietary intake of omega-3 fatty acids in patients diagnosed with CHD.Methodology: A systematic review of evidence-based literature was performed using Medline and Cochrane databases.Inclusion criteria included 1) randomized controlled trials (RCT) comparing dietary or supplemental intake of omega-3 fatty acids with a control diet or placebo, 2) trials reporting cardiac endpoints including fatal or nonfatal myocardial infarction and overall mortality, 3) trials following patients with established CHD for at least 6 months.Results: Six RCTs and two meta-analyses were included.Research shows supplementation with omega-3 fatty acids decreases the incidence of myocardial reinfarction, sudden death due to fatal cardiac arrhythmias, and all cause mortality.However, although individual studies reviewed were of high quality, when compared, their findings were inconsistent.Conclusion: There is insufficient evidence to recommend the use of omega-3 fatty acids for secondary prevention of myocardial reinfarction in patients with existing CHD.
Authors: Abigail M. Moos, Sue M. Nyberg
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1567944579