Oxidative Stress in Diabetic Nephropathy
Year: 2013
Type: article
Abstract: Diabetic nephropathy (DN) is one of the complications of diabetes. The presence of high serum glucose concentrations can cause an irreversible progression of renal dysfunction, including glomerulosclerosis, arteriolar hyalinosis, and tubulointerstitial fibrosis. Oxidative stress has been linked to the pathogenesis of DN. The major sources of reactive oxygen species (ROS) in kidney are induced by the polyl pathway, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, protein kinase C (PKC), and advanced glycation end products (AGEs). A huge increase in ROS can cause protein denaturation and cell death by changing protein sensors or intracellular signaling pathways. In addition to the traditional clinical strategies of controlling glucose and dietary protein, providing antihypertensive treatment, and reducing hyperlipidemia, there are several new approaches to the treatment of diabetic nephropathy that are based on decreasing ROS. Here we review recent research describing the relationship between oxidative stress and DN, and the application of antioxidants to the treatment of DN.
Source: 童綜合醫學雜誌
Authors: Huei-Jane Lee, Wen‐Chin Lee
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1569579747