Selective Expansion of the Monocytic Lineage Directed by Bacterial Infection
Year: 2009
Type: article
Abstract: CCR2-mediated recruitment of Ly6C(high) monocytes is essential for defense against a range of microbial pathogens. Although our understanding of monocyte trafficking to inflammatory sites is increasing, how innate immune inflammation influences monocyte development and maturation during microbial infection remains undefined. Herein, we demonstrate that infection with the intracellular bacterial pathogen Listeria monocytogenes specifically and selectively promotes monopoiesis. Systemic infection with virulent L. monocytogenes induces marked proliferation of bone marrow monocyte precursors and results in depletion of myeloid progenitors. Proliferation of monocyte precursors correlates with the intensity of systemic infection and is unaffected by the density of monocytes in the bone marrow. Although MyD88/Trif-mediated signaling is not required for early emigration of the mature monocyte population from the bone marrow, replenishment of monocyte populations depends on MyD88/Trif. Our studies demonstrate that TLR-mediated signals play an essential role in the maintenance of monocyte homeostasis during systemic bacterial infection.
Source: The Journal of Immunology
Institution: Memorial Sloan Kettering Cancer Center
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: Immunobiology of Allogeneic Hematopoietic Cell Transplantation, CD4 T Cell Responses to M. Tuberculosis Infection, Monocyte-mediated Host Defense against Aspergillus fumigatus, G2778686178, CC-chemokines in Listeria infection., MSKCC Clinical Oncology Research Career Development Program, G8568240630
OpenAlex ID: W1570257210