Work

cis-Polyunsaturated fatty acids induce high levels of superoxide production by human neutrophils.

Year: 1981

Type: article

Abstract: Arachidonate stimulates the production of large quantities of superoxide by human neutrophils: 93.8 +/- 12.5 S.D. nmol of O2(-)/min/10(7) cells. This rate is comparable to that observed with the most effective neutrophil-stimulating agents previously reported. Other cis-unsaturated fatty acids are also capable of eliciting this response, the order of effectiveness being: arachidonate greater than gamma-linolenate greater than linoleate greater than oleate. Linolelaidate, myristate, and palmitate are ineffective. These data are discussed in relation to recent reports concerning the oxidation of arachidonic acid by human neutrophils and by a cell-free system that generates superoxide and hydrogen peroxide.

Source: Journal of Biological Chemistry

DOI: 10.1016/s0021-9258(18)42939-0

Authors: J.A. Badwey, J.T. Curnutte, M.L. Karnovsky

Language: English

Topic: Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430

OpenAlex ID: W1570720342

FWCI: 3.809

Cites: 38

Cited by: 209

Related to: 10